Analysis of mitochondrial DNA mutations as a possible cause of Multiple Sclerosis
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چکیده
As with chromosomal DNA, the DNA located in mitochondria (mitochondrial DNA or mtDNA) can contain mutations that are highly pathogenic. In fact, many diseases of the central nervous system are known to be caused by mutations in mtDNA. The possibility that mtDNA mutations contribute to susceptibility to MS has been approached from several different angles, the most well-studied of which has been the apparent connection between MS and the mitochondrial disease Leber hereditary optic neuropathy.
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